What You Will Do
The successful candidate will join a multi-institutional cancer-relevant systems biology project team supported by the National Institutes of Health. You will be affiliated with the Theoretical Biology & Biophysics Group, which is part of the Laboratory's Theoretical Division. In the project, you will be responsible for helping to develop mathematical models that are useful for analyzing how combinations of protein kinase inhibitors affect activation of oncogenic ERK signaling. The models of interest will incorporate structural constraints, which will be inferred from available 3D structures. Models will be parameterized for consistency with experimental data generated by experimental team members. There may be an opportunity to analyze data from a clinical trial. We are trying to find novel strategies for using kinase inhibitors to kill cancer cells harboring driver mutations in RAS and RAF genes.
What You Need
Minimum Job Requirements:
An ability to learn how to create molecular models for protein complexes from available 3D structures
An ability to learn rule-based modeling techniques
An ability to learn Bayesian inference and statistical computing methods
Must be able to independently learn how to use scientific software packages
Scientific programming skills
Familiarity with Python
A strong biological background
Education/Experience : The candidate must have an undergraduate degree and be actively seeking a PhD degree at a university.
Experience using the BioNetGen software package
Experience using the PyBioNetFit software package
Note to Applicants:
You must be able to work at LANL while fulfilling PhD degree requirements.
Location: This position will be physically located in Los Alamos, NM.
Where You Will Work
Located in beautiful northern New Mexico, Los Alamos National Laboratory (LANL) is a multidisciplinary research institution engaged in strategic science on behalf of national security. Our generous benefits package includes:
§ PPO or High Deductible medical insurance with the same large nationwide network
§ Dental and vision insurance
§ Free basic life and disability insurance
§ Paid maternity and parental leave
§ Award-winning 401(k) (6% matching plus 3.5% annually)
§ Learning opportunities and tuition assistance
§ Flexible schedules and time off (paid sick, vacation, and holidays)
§ Onsite gyms and wellness programs
§ Extensive relocation packages (outside a 50 mile radius)
Directive 206.2 - Employment with Triad requires a favorable decision by NNSA indicating employee is suitable under NNSA Supplemental Directive 206.2 . Please note that this requirement applies only to citizens of the United States. Foreign nationals are subject to a similar requirement under DOE Order 142.3A.
No Clearance: Position does not require a security clearance. Selected candidates will be subject to drug testing and other pre-employment background checks.
New-Employment Drug Test: The Laboratory requires successful applicants to complete a new-employment drug test and maintains a substance abuse policy that includes random drug testing.
Internal Applicants: Regular appointment employees who have served the required period of continuous service in their current position are eligible to apply for posted jobs throughout the Laboratory. If an employee has not served the required period of continuous service, they may only apply for Laboratory jobs with the documented approval of their Division Leader. Please refer to PolicyPolicy P701for applicant eligibility requirements.
For general program information refer to the Student Programs web page.
Equal Opportunity: Los Alamos National Laboratory is an equal opportunity employer and supports a diverse and inclusive workforce. All employment practices are based on qualification and merit, without regard to race, color, national origin, ancestry, religion, age, sex, gender identity, sexual orientation or preference, marital status or spousal affiliation, physical or mental disability, medical conditions, pregnancy, status as a protected veteran, genetic information, or citizenship within the limits imposed by federal laws and regulations. The Laboratory is also committed to making our workplace accessible to individuals with disabilities and will provide reasonable accommodations, upon request, for individuals to participate in the application and hiring process. To request such an accommodation, please send an email to ~~~ or call ~~~ option 1.
Instructions on How to Activate/Create a LANL Jobs Account:
Follow the instructions below if you have ever had an employee Z number, been a contractor, or received Los Alamos Lab insurance coverage to activate your account:
Select the Click Here button if you have been employed with the Lab or received insurance coverage .
Please enter only your first and last name and current email address (an email with your validation code will be sent to you) to activate the account currently in our system.
Enter your validation code as described in the email you receive and complete the 3-page registration form. Your account is now active and you can apply for jobs or save to your basket. Important : Enter the validation code within 15 days to activate your account or your account will be deactivated.
Follow the instructions below if you if you have never been employed with the Lab or received insurance coverage to create an account:
Select the Register button if you have never been employed with the Lab or received insurance coverage to Create an Account.
From here, you will establish an account with username and password.
How to Apply: Login to Your Account to Complete the Application Process
Click the Vacancy Name number (in blue) to view any job's details.
Click Apply or Add to Basket to apply later. Tip : To apply for a job or save your basket, you must have a LANL jobs account.
If you experience any technical issues, please email ~~~ for assistance.
Contact Name Vigil, Melanie Louise
Vacancy Name: IRC85748
Organization Name T-6/Theoretical - Theoretical Biology And Biophysics
Req ID: IRC85748
Category: Student - Graduate